منابع مشابه
Halogenation Generates Effective Modulators of Amyloid-Beta Aggregation and Neurotoxicity
Halogenation of organic compounds plays diverse roles in biochemistry, including selective chemical modification of proteins and improved oral absorption/blood-brain barrier permeability of drug candidates. Moreover, halogenation of aromatic molecules greatly affects aromatic interaction-mediated self-assembly processes, including amyloid fibril formation. Perturbation of the aromatic interacti...
متن کاملResearch Paper: The Effect of Callistephin on Amyloid Beta-Induced Neurotoxicity in the Hippocampus of Male Rats
Introduction: Oxidative stress plays a key role in the pathophysiology of the Alzheimer's disease and it seems that antioxidants may slow the progress of the disease. The current study aimed at investigating the possible protective effects of callistephin (a natural flavonoid) against amyloid β (Aβ)-induced neurogenesis deficits in rats. Methods: Adult Wistar male rats in the current...
متن کاملAttenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation.
Aggregation of the amyloid-beta (Abeta) peptide into amyloid plaques is a characteristic feature of Alzheimer's disease neuropathogenesis. We and others have previously demonstrated delayed Abeta aggregation as a consequence of oxidizing a single methionine residue at position 35 (Met-35). Here, we examined the consequences of Met-35 oxidation on the extremely aggregation-prone peptides Abeta1-...
متن کاملRed wine ingredient resveratrol protects from beta-amyloid neurotoxicity.
BACKGROUND beta-Amyloid peptide (Abeta), a neutrotoxic substance, has been implicated to a great degree in cell death during the course of AD. Resveratrol, a natural polyphenol mainly found in red wine, has been shown to be cardioprotective and chemoprotective. Since a moderate wine intake correlates with a lower risk for Alzheimer disease (AD), an additional neuroprotective effect has been pos...
متن کاملNicotinic receptor-mediated protection against beta-amyloid neurotoxicity.
Multiple lines of evidence, from molecular and cellular to epidemiologic, have implicated nicotinic transmission in the pathology of Alzheimer's disease. In this review we present evidence for nicotinic receptor-mediated protection against beta-amyloid and glutamate neurotoxicity, and the signal transduction involved in this mechanism. The data are based mainly on our studies using rat-cultured...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2000
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.115.67